STOP the fat coming back!

Nutrient Partitioning: Why Your Body Stores More Fat in Midlife

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Why does it seem like you can eat the same way you always have, yet your body composition keeps changing?

In this episode of Midlife Mayhem, Joanne Lee Cornish breaks down nutrient partitioning — how your body uses the calories you consume and why, as we age, more of those calories may be stored as fat rather than used to support muscle, movement, and energy expenditure.

Joanne also discusses 5-Amino-1MQ, the molecule that caught her attention because of research into its potential effects on fat storage.

In This Episode

1. Nutrient Partitioning Explained

Calories in versus calories out is only part of the story. Joanne explains the four potential destinations for excess calories:

• Muscle growth and glycogen storage

• Non-exercise activity thermogenesis (NEAT)

• Heat production

• Fat storage

2. Why Body Composition Changes in Midlife

As we age, we tend to move less, lose muscle, and become less responsive to the signals that support muscle growth and maintenance. These changes can affect how our bodies use and store energy.

3. Muscle Is Key to Successful Aging

Consistent resistance training, progressive overload, and adequate protein are essential to supporting muscle as we age. Joanne explains why repeating the same workouts without progression may not provide the stimulus your muscles need.

4. The Problem With Rapid Weight Loss

Losing weight quickly can mean losing muscle alongside fat. When muscle mass and daily movement decline, your body may burn fewer calories than before, making weight regain more likely to consist primarily of fat.

5. Hormones, Insulin Resistance, and Changing Fat Distribution

Joanne discusses how declining estrogen and testosterone can influence where fat accumulates, particularly around the midsection, and why muscle health and insulin sensitivity matter.

6. 5-Amino-1MQ and Fat Storage

What caught Joanne's attention about 5-Amino-1MQ was research investigating its effect on NNMT, an enzyme associated with fat tissue and metabolism.

She discusses research in mice investigating reduced fat accumulation and fat loss, even under conditions designed to promote obesity, and explores how these findings relate to nutrient partitioning.

The Takeaway

You cannot outsource the work of building and preserving muscle.

If you want to improve your body composition in midlife, focus on consistent resistance training, adequate protein, progressive overload, and more daily movement.

Understanding nutrient partitioning gives you another way to look at why your body changes — and what you can do to support your goals.

Interested in 5-Amino-1MQ?

Joanne shares her experience with 5-Amino-1MQ and discusses the research that sparked her interest in this molecule.

Explore 5-Amino-1MQ and shop Joanne's products:

https://www.joanneleestore.com

Connect with Joanne

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If you found this episode useful, subscribe to Midlife Mayhem and share it with someone who wants to better understand muscle, metabolism, and body composition in midlife.